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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE4D
All Species:
16.06
Human Site:
S752
Identified Species:
39.26
UniProt:
Q08499
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q08499
NP_001098101.1
809
91115
S752
E
S
D
T
E
K
D
S
G
S
Q
V
E
E
D
Chimpanzee
Pan troglodytes
XP_001138439
809
91104
S752
E
S
D
T
E
K
D
S
G
S
Q
V
E
E
D
Rhesus Macaque
Macaca mulatta
XP_001101097
595
67340
E543
K
D
S
G
S
Q
V
E
E
D
T
S
C
S
D
Dog
Lupus familis
XP_544349
792
88684
S735
E
S
D
T
E
K
D
S
G
S
Q
V
E
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q01063
747
84544
V695
E
K
D
S
G
S
Q
V
E
E
D
T
S
C
S
Rat
Rattus norvegicus
P14270
803
90534
S747
E
S
D
T
E
K
D
S
G
S
Q
V
E
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086133
721
82347
T669
E
K
F
H
F
E
L
T
L
E
E
E
D
S
D
Zebra Danio
Brachydanio rerio
XP_695374
745
84839
D693
S
K
T
L
C
T
Q
D
S
E
C
T
E
I
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P12252
1070
115060
A1015
E
S
D
Q
E
N
L
A
E
L
E
E
G
D
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22000
674
75370
Y622
S
Q
V
G
F
I
D
Y
I
V
H
P
L
Y
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
67.8
84
N.A.
83.5
97
N.A.
N.A.
N.A.
65
75.7
N.A.
42.1
N.A.
44.8
N.A.
Protein Similarity:
100
99.6
70.2
86.1
N.A.
86.1
97.5
N.A.
N.A.
N.A.
75.2
81.2
N.A.
53.5
N.A.
59.5
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
13.3
100
N.A.
N.A.
N.A.
13.3
6.6
N.A.
26.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
20
100
N.A.
20
100
N.A.
N.A.
N.A.
40
6.6
N.A.
53.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
10
0
0
0
0
0
10
0
10
10
0
% C
% Asp:
0
10
60
0
0
0
50
10
0
10
10
0
10
10
60
% D
% Glu:
70
0
0
0
50
10
0
10
30
30
20
20
50
40
20
% E
% Phe:
0
0
10
0
20
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
20
10
0
0
0
40
0
0
0
10
0
0
% G
% His:
0
0
0
10
0
0
0
0
0
0
10
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
10
0
0
0
0
10
0
% I
% Lys:
10
30
0
0
0
40
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
10
0
0
20
0
10
10
0
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% P
% Gln:
0
10
0
10
0
10
20
0
0
0
40
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
20
50
10
10
10
10
0
40
10
40
0
10
10
20
10
% S
% Thr:
0
0
10
40
0
10
0
10
0
0
10
20
0
0
0
% T
% Val:
0
0
10
0
0
0
10
10
0
10
0
40
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
10
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _